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The FAA constantly updates its list of approved and not approved medications. Below is a list of specifically not approved meds that the FAA has instructed AMEs (aviation medical examiners) to not issue a Medical Certificate if a pilot is currently taking them. Just becuase you do have a valid medical, does not mean you can go and start taking medication without first talking with your AME. Only an AME physician has the knowledge of what is and is not approved by the FAA for Pilots.
Do Not Issue. AMEs should not issue airmen medical certificates to applicants who are using these classes of medications or medications.
Do Not Fly. Airmen should not fly while using any of the medications in the Do Not Issue section above or while using any of the medications or classes/groups of medications listed below without an acceptable wait time after the last dose. The FAA is concerned that even without any feeling of impairment you may still not be fully alert and fit to fly.
The FAA also has a list of prohibited meds that you can still fly after taking as long as enough time has passed since the last dose. There are two rules they follow to determine how long you have to wait after taking your last dose:
Airmen should not fly while using any medication, prescription or OTC, that carries a label precaution or warning that it may cause drowsiness or advises the user “be careful when driving a motor vehicle or operating machinery.” This applies even if label states “until you know how the medication affects you” and even if the airman has used the medication before with no apparent adverse effect.
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